Background: Patients with rectal cancer who achieve pathologic complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT) may have a better prognosis and may be eligible for non-operative management.The aim of this research was to identify variables for predicting pCR in rectal cancer patients after nCRT and to define clinical risk factors
Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is a highly conserved multifunctional enzyme, and its catalytic activity is stimulated by DNA breaks.The activation of PARP-1 and subsequent depletion of nicotinamide adenine dinucleotide (NAD+) and adenosine triphosphate (ATP) contributes to significant cytotoxicity in inflammation of various etiolo
Immune checkpoint blockade is the exciting breakthrough in cancer, but how immune checkpoints are activated is unknown.We have earlier reported that cell-free chromatin particles (cfChPs) that circulate in blood of cancer patients, or those that are released locally from dying cancer cells, are readily internalized by healthy cells with biological
Acute respiratory distress syndrome (ARDS) is common among mechanically ventilated children, and accompanies up to 30% of all PICU deaths.Though ARDS diagnosis is based on clinical criteria, biological markers of acute lung damage have been extensively studied in adults and children.Biomarkers of inflammation, alveolar epithelial and capillary endo